RESEARCH

  • A New Standard For Clinical Mass Spectrometry - Clinical Chemistry

    Mass spectrometry is an analytical technique that separates molecules based on their weight (mass) and fragmentation pattern. Identification is based on the fact that each drug has a specific mass and breakdown in the same way that each person has a specific fingerprint.
  • Report From The Scientific Working Group For Forensic Toxicology 2018

    Validation is the process of performing a set of experiments that reliably estimates the efficacy and reliability of an analytical method or modification to a previously validated method. The goal of validation is to establish objective evidence that demonstrates a method is capable of successfully performing at the level of its intended use and to identify the method’s limitations under normal operating conditions. The steps provided in this document will ensure that the minimum standards of practice for validating analytical methods in forensic toxicology have been performed. While it is acknowledged that method performance may vary somewhat during day-to-day analysis of actual case samples, the validation parameters evaluated with this practice serve as estimates of a method’s true performance.

  • Bioanalytical Method Validation 2018

    This guidance helps sponsors of investigational new drug applications (INDs) or applicants of new drug applications (NDAs), abbreviated new drug applications (ANDAs), biologic license applications (BLAs), and supplements validate bioanalytical methods used in human clinical pharmacology, bioavailability (BA), and bioequivalence (BE) studies that require pharmacokinetic, toxicokinetic, or biomarker concentration evaluation.
  • Labs Performing UDT

    Mass spectrometry is an analytical technique that separates molecules based on their weight (mass) and fragmentation pattern. Identification is based on the fact that each drug has a specific mass and breakdown in the same way that each person has a specific fingerprint.
  • Mass Spectrometry Increases Specificity

    Unlike immunoassays or high-pressure liquid chromatography assays using ultraviolet or fluorescence detection, mass spectrometry offers better specificity and reduced interferences if attention is paid to potential isobaric compounds. 
  • LCMS Reduces Lab Costs

    The applications of liquid chromatography (LC) in combination with tandem mass spectrometry (MS/MS) are of increasing importance as an analytical tool in clinical laboratory diagnostics.
  • Laboratories Utilizing LC-MS/MS

    Reference laboratories utilizing LC-MS/MS technology to conduct urine drug testing for pain clinicians should employ specific techniques described in this study to develop an optimal test menu and validate procedures that include isolating retention times for isobaric compounds, identifying interfering substances including impurities in medicinal and illicit substance preparations, monitoring ion suppression, and avoiding carryover.