Laboratories Utilizing LC-MS/MS

Reference laboratories utilizing LC-MS/MS technology to conduct urine drug testing for pain clinicians should employ specific techniques described in this study to develop an optimal test menu and validate procedures that include isolating retention times for isobaric compounds, identifying interfering substances including impurities in medicinal and illicit substance preparations, monitoring ion suppression, and avoiding carryover.

Pesce, A., West, C., West, R., Latyshev, S., Masters-Moore, D., Friel, P., … Mikel, C. (2012). Analytical & Bioanalytical Analytical Considerations When Monitoring Pain Medications by LC-MS / MS. Journal of Analytical & Bioanalytical Techniques.

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