Mass Spectrometry Increases Specificity

Unlike immunoassays or high-pressure liquid chromatography assays using ultraviolet or fluorescence detection, mass spectrometry offers better specificity and reduced interferences if attention is paid to potential isobaric compounds. Furthermore, multiplexing, which enables multiple analytes to be measured with the same volume of serum is advantageous, and the requirement for large sample volumes is decreasing as instrument sensitivity increases.

Adaway, J. E., Keevil, B. G., & Owen, L. J. (2015). Liquid chromatography tandem mass spectrometry in the clinical laboratory. Annals of Clinical Biochemistry, 52(1), 18–38.

https://doi.org/10.1177/0004563214557678

http://journals.sagepub.com/doi/pdf/10.1177/0004563214557678

Leave a comment

Name .
.
Message .

Please note, comments must be approved before they are published