Mass Spectrometry Increases Specificity
Unlike immunoassays or high-pressure liquid chromatography assays using ultraviolet or fluorescence detection, mass spectrometry offers better specificity and reduced interferences if attention is paid to potential isobaric compounds. Furthermore, multiplexing, which enables multiple analytes to be measured with the same volume of serum is advantageous, and the requirement for large sample volumes is decreasing as instrument sensitivity increases.
Adaway, J. E., Keevil, B. G., & Owen, L. J. (2015). Liquid chromatography tandem mass spectrometry in the clinical laboratory. Annals of Clinical Biochemistry, 52(1), 18–38.